Diagnosis of HSIL

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Background

HSILHigh-grade squamous intraepithelial lesionIn the Australian context, HSIL is used to refer to a cytology predictive of a high grade precancerous lesion (AMBS 2004), or histologically confirmed high grade precancerous lesion (HSIL-CIN2 or HSIL-CIN3 as per LAST terminology). may be suspected from the cytological examination of cells from a cervical smear or LBCLiquid based cytology(LBC) is a way of preparing cervical samples for examination in the laboratory. preparation. However, in Australia it has been considered best practice to establish the final diagnosis on histopathological examination of tissue obtained from cervical punch biopsy or an excisional procedure.

Histological diagnosis of HSILHigh-grade squamous intraepithelial lesionIn the Australian context, HSIL is used to refer to a cytology predictive of a high grade precancerous lesion (AMBS 2004), or histologically confirmed high grade precancerous lesion (HSIL-CIN2 or HSIL-CIN3 as per LAST terminology). (CIN2/3) is necessary before proceeding to treatment, except in certain circumstances. Treatment undertaken at the time of initial colposcopic assessment is known as ‘treatment at first visit’ or ‘see-and-treat’ (see Treatment at first visit in Chapter 7. Colposcopy).

Recommendation

Consensus-based recommendation*Question mark transparent.png

REC10.1: Histological diagnosis prior to treatment
For women who have a visible lesion at colposcopy, histological confirmation of HSILHigh-grade squamous intraepithelial lesionIn the Australian context, HSIL is used to refer to a cytology predictive of a high grade precancerous lesion (AMBS 2004), or histologically confirmed high grade precancerous lesion (HSIL-CIN2 or HSIL-CIN3 as per LAST terminology). is recommended before undertaking definitive treatment.

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