COSA:AYA cancer fertility preservation/Impact of cancer treatments on fertility/Table risk CT and RT

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Fertility preservation for AYAs diagnosed with cancer: Guidance for health professionals. > COSA:AYA cancer fertility preservation/Impact of cancer treatments on fertility/Table risk CT and RT

Table 1: Representative rates of ovarian failure after treatment of common childhood and young adult cancers *

Disease Likelihood of premature ovarian failure
Breast cancer (treated with chemotherapy)
Age <30 years < 10%
Age 30–40 years 20 – 40%
Sarcoma < 10 – 40%
Hodgkin lymphoma ≥ 5% unless intensive therapy (However the risk of later onset of premature ovarian failure is 19%; average 9 years after treatment, onset of permanent ovarian failure at mean age 33.5 years) [1]


40 – 60% if escalated therapy

non-Hodgkin lymphoma 10 – 40%
Leukaemia < 10%
High-dose therapy and stem-cell transplantation > 70 – 90%

Modified from Stern CJ, Toledo MG, Good DA, Seymour JF. Fertility preservation in female oncology patients. Aust NZ J Obstet Gynaecol 2006; 46(1): 15-23. http://www.ncbi.nlm.nih.gov/pubmed/16441687

* This table presents representative rates of ovarian failure after treatment (average >2 years after treatment), but does not consider any additional established risk of later premature ovarian failure.

References

  1. De Bruin ML, Huisbrink J, Hauptmann M, Kuenen MA, Ouwens GM, van't Veer MB, et al. Treatment-related risk factors for premature menopause following Hodgkin lymphoma. Blood 2008 Jan 1;111(1):101-8 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/17890454.