COSA:AYA cancer fertility preservation/Options for fertility preservation/Cryopreservation of epididymal or testicular extracted sperm
Cryopreservation of epididymal or testicular extracted sperm
When it is not possible to obtain an ejaculate, or when the semen contains no sperm because of previous damage to spermatogenesis or obstruction of the vas deferens, it may be possible to obtain sperm by direct testicular or epididymal aspiration or biopsy. Sperm suitable for use in ICSI may also be extracted from orchidectomy specimens from males with testicular cancer.
Risks and side effects
There is no evidence that a history of treated cancer increases the rate of congenital abnormalities or cancer in a man’s children. Higher rates of sperm aneuploidy have been reported to occur for up to 18 months after chemotherapy and radiotherapy.
Freeze thawing of sperm in non-cancer patients has not been associated with any increased risk of adverse outcomes in assisted reproduction treatments. However overall, assisted reproduction (both IVF and ICSI) is associated with a slightly increased risk – 6.4 per 100 births, compared to 4.8 per 100 births from unassisted conception, which equates to one extra birth defect for every 62 births.
Depends on treatment centre.
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