Citation:Johansson JE, Andersson SO, Holmberg L, Bergström R 1991

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Johansson JE, Andersson SO, Holmberg L, Bergström R. Primary orchiectomy versus estrogen therapy in advanced prostatic cancer--a randomized study: results after 7 to 10 years of followup. J Urol 1991 Mar;145(3):519-22; discussion 522-3 Available from:

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  1. What should be done for patients with locally advanced disease who are not suitable candidates for surgery or radiotherapy – primary androgen deprivation at diagnosis or wait until clinical progression (localized or metastatic)?