Clinical question comments:After hysterectomy, what is the role of radiotherapy (external beam, brachytherapy) in the management of early stage high risk endometrial cancer?/Stage 1 endometrial cancer

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General information on how to comment

• If you have identified any gaps or errors in the content please suggest suitable text for inclusion.
• Statements regarding the inclusion/exclusion of issues should be clearly supported by scientific evidence.

Do you mean Portec 2 rather than Portec 28?

Thank you for your comment. You are correct, this was a typographical error. 8 is the reference number and this has now been inserted next to the 2 in the text and also listed in the reference list. Regards, Christine Vuletich Manager, Clinical Guidelines Network Cancer Council Australia

"Blake et al[4] in the most recent meta-analysis does not support any overall survival benefit with pelvic EBRT"

Consideration should be given to including at statement regarding the benefit that pelvic and vaginal vault brachytherapy does provide. Ida Ackerman comments in the IJGC Supplement in Sept 2010 on this topic quite eloquently. It is useful to bear in mind the progression-free survival benefit from radiotherapy (both EBRT & VBT).

Dr Pearly Khaw Radiation Oncologist Peter MacCallum Cancer Centre

Sorry, I should have added, "even though this is stated in your recommendations". I believe this does need to be emphasised. Pearly

Dear Dr Khaw,

Thank you for providing comment on the draft guidelines.

The Working Party has recently met to consider all the public comments received and review the guidelines.

The following is their response to your comments above:

Leave as is. The current recommendation does make that statement, however, can’t be made stronger because the evidence does not allow it. Not strong enough evidence to include the suggested reference in the evidence summary.

Christine Vuletich

Manager, Clinical Guidelines Network

Cancer Council Australia