Clinical question comments:What is the evidence based surgical approach for lymphadenectomy in low and high risk apparent early stage endometrial cancer?/Lymphadenectomy in patients with non- endometrioid endometrial cancer

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Public comments: Lymphadenectomy in patients with non- endometroid endometrial cancer217:58, 5 October 2012

Public comments: Lymphadenectomy in patients with non- endometroid endometrial cancer

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General information on how to comment

  • If you have identified any gaps or errors in the content please suggest suitable text for inclusion.
  • Statements regarding the inclusion/exclusion of issues should be clearly supported by scientific evidence.


Jutta von Dincklage14:40, 17 June 2011

The studies differed with respect to adjuvant therapy; the ASTEC trial had a factorial design in which post-surgical high risk women eligible for adjuvant RXT were further randomised to RXT independently of lymph node status. This resulted in identical proportions receiving adjuvant RXT between the lymphadenectomy and no lymphadenectomy arms, whereas in the Italian study a higher proportion of women in the lymphadenectomy arm received chemotherapy. Now some evidence for adjuvant chemo and survival... Hogberg T, Signorelli M, Freire de Oliveira C et al. Sequential adjuvant chemotherapy and radiotherapy in endometrial cancer – Results from two randomised studies EJC 2010; 46(13): 2422-2431 Rationale for nodes and omentum in non-endometriod tumours surely the same as that for endometrioid?? MQ

165.228.90.7912:50, 8 July 2011

Dear Prof Quin,

Thank you for providing comment on the draft guidelines.

The Working Party has recently met to consider all the public comments received and review the guidelines.

The following is their response to your comments above:

Not sure if these comments relate to this section. Further clarification needed.

Christine Vuletich

Manager, Cancer Guidelines Network Cancer Council Australia

Christine Vuletich11:33, 28 September 2011