Critical appraisal:Ackroyd R, Brown NJ, Davis MF, Stephenson TJ, Marcus SL, Stoddard CJ, et al 2000 2

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Critical Appraisal

Article being appraised

Ackroyd R, Brown NJ, Davis MF, Stephenson TJ, Marcus SL, Stoddard CJ, et al. Photodynamic therapy for dysplastic Barrett's oesophagus: a prospective, double blind, randomised, placebo controlled trial. Gut 2000 Nov;47(5):612-7 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/11034574.


Applicable clinical question

Key Facts

Study Design

case series

Number of Patients:

40


Includes an economic evaluation

no

Evidence ratings

Level of evidence

IV

Risk of bias
High risk of bias Comments: Looks like had complete follow up of all 40 patients for 1,6,12 months. Estimated area of Barrett's which is novel, but no detailed description of how did this. Specifically focused on LGD

Risk of bias assessment: case series

Subject selection:
Highly selected or not described (e.g. single-institution study)
Were the outcome measures blind to pre/post-intervention?
No, but objective measures used
Follow-up complete and all patients included in the analysis?
Yes (follow-up >95%)
Size of effect
5 Reason for decision: Not possible to calculate statistic on size of effect as not comparative, though appears high as 39/40 no LGD on f/u
Relevance of evidence
2 Additional comments: Specifically addresses impact on LGD with intervention of PDT, but doesnt address mortality or QOL
Result of appraisal

Jutta's tick icon.png Included




Completed by

Dr Andrew Taylor MBBS MD FRACP


Jutta's tick icon.png This appraisal has been completed.


Article
Ackroyd R, Brown NJ, Davis MF, Stephenson TJ, Marcus SL, Stoddard CJ, et al. Photodynamic therapy for dysplastic Barrett's oesophagus: a prospective, double blind, randomised, placebo controlled trial. Gut 2000 Nov;47(5):612-7 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/11034574.
Assigned to
User:Andrew.taylor
Topic area
Guidelines:Barrett's
Clinical question
Form
Form:Critical appraisal


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