Critical appraisal:Ackroyd R, Brown NJ, Davis MF, Stephenson TJ, Stoddard CJ, Reed MW 2000

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Critical Appraisal

Article being appraised

Ackroyd R, Brown NJ, Davis MF, Stephenson TJ, Stoddard CJ, Reed MW. Aminolevulinic acid-induced photodynamic therapy: safe and effective ablation of dysplasia in Barrett's esophagus. Dis Esophagus 2000;13(1):18-22 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/11005326.


Applicable clinical question

Key Facts

Study Design

case series

Number of Patients:

40


Includes an economic evaluation

no

Evidence ratings

Level of evidence

IV

Risk of bias
High risk of bias Comments: Main endpoint is low grade dysplasia eradication after PDT. Based on "multiple biopsies", but biopsy protocol not stated. Although LGD not present on followup bs ins 39/40, reduction in Barrett's area only 30%

Risk of bias assessment: case series

Subject selection:
Highly selected or not described (e.g. single-institution study)
Were the outcome measures blind to pre/post-intervention?
No, but objective measures used
Follow-up complete and all patients included in the analysis?
Yes (follow-up >95%)
Size of effect
5 Reason for decision: No comparison with no treatment to calculate significance of result
Relevance of evidence
2 Additional comments: Please replace this text and briefly describe the reasons for your rating
Result of appraisal

Jutta's tick icon.png Included




Completed by

Dr Andrew Taylor MBBS MD FRACP


Jutta's tick icon.png This appraisal has been completed.


Article
Ackroyd R, Brown NJ, Davis MF, Stephenson TJ, Stoddard CJ, Reed MW. Aminolevulinic acid-induced photodynamic therapy: safe and effective ablation of dysplasia in Barrett's esophagus. Dis Esophagus 2000;13(1):18-22 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/11005326.
Assigned to
User:Andrew.taylor
Topic area
Guidelines:Barrett's
Clinical question
Form
Form:Critical appraisal


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