Critical appraisal:Ackroyd R, Kelty CJ, Brown NJ, Stephenson TJ, Stoddard CJ, Reed MW 2003

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Critical Appraisal

Article being appraised

Ackroyd R, Kelty CJ, Brown NJ, Stephenson TJ, Stoddard CJ, Reed MW. Eradication of dysplastic Barrett's oesophagus using photodynamic therapy: long-term follow-up. Endoscopy 2003 Jun;35(6):496-501 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/12783347.


Applicable clinical question

Key Facts

Study Design

case series

Number of Patients:

40


Includes an economic evaluation

no

Evidence ratings

Level of evidence

IV

Risk of bias
High risk of bias Comments: Abstract only

Details of follow programme not described

Risk of bias assessment: case series

Subject selection:
Highly selected or not described (e.g. single-institution study)
Were the outcome measures blind to pre/post-intervention?
No, but objective measures used
Follow-up complete and all patients included in the analysis?
Reasonable (follow-up >80%)
Size of effect
5 Reason for decision: No comparative data with non-treatment. Presence of LGD can fluctuate and depend on biopsy locations and protocols
Relevance of evidence
2 Additional comments: Appears to show persistent effect in downgrading LGD Barrett's to non-dysplastic with 3-4 year followup
Result of appraisal

Jutta's tick icon.png Included




Completed by

Dr Andrew Taylor MBBS MD FRACP


Jutta's tick icon.png This appraisal has been completed.


Article
Ackroyd R, Kelty CJ, Brown NJ, Stephenson TJ, Stoddard CJ, Reed MW. Eradication of dysplastic Barrett's oesophagus using photodynamic therapy: long-term follow-up. Endoscopy 2003 Jun;35(6):496-501 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/12783347.
Assigned to
User:Andrew.taylor
Topic area
Guidelines:Barrett's
Clinical question
Form
Form:Critical appraisal


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