Critical appraisal:Ackroyd R, Tam W, Schoeman M, Devitt PG, Watson DI 2004

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Critical Appraisal

Article being appraised

Ackroyd R, Tam W, Schoeman M, Devitt PG, Watson DI. Prospective randomized controlled trial of argon plasma coagulation ablation vs. endoscopic surveillance of patients with Barrett's esophagus after antireflux surgery. Gastrointest Endosc 2004 Jan;59(1):1-7 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/14722539.


Applicable clinical question

Key Facts

Study Design

randomised controlled trial

Number of Patients:

40


Includes an economic evaluation

no

Evidence ratings

Level of evidence

II

Risk of bias
High risk of bias Comments: Well conducted study with good randomisation and follow up to 12 months. Outcome assessments however were not blinded.

Risk of bias assessment: randomised controlled trial

Was the trial double-blinded?
Outcomes not blinded, substantial side-effects, or not reported.
Was the treatment allocation schedule concealed?
Adequately concealed (e.g. central randomisation, numbered or coded bottles, drugs prepared by pharmacy).
Were all randomised participants included in the analysis?
No exclusions or survival analysis used with all subjects included (>95% follow-up for all groups).
The field below is not considered when calculating the risk of bias rating
How was the allocation schedule generated?
Adequate (e.g. random number table, computer random generator, coin tossing, card shuffling)
Size of effect
2 Reason for decision: The treatment arm had a very significantly different outcome that the control arm.
Relevance of evidence
2 Additional comments: The study was largely conducted in patients with non-dysplastic Barrett's. There were two patients in the surveillance arm that had LGD at inclusion but this resolved during follow up.
Result of appraisal

Jutta's tick icon.png Included



Comments

This cohort is the same study population as reported in the Bright et al paper from 2007 published in the Annals of Surgery

Completed by

Dr Mark Schoeman MBBS, PhD, FRACP, AGAF


Jutta's tick icon.png This appraisal has been completed.


Article
Ackroyd R, Tam W, Schoeman M, Devitt PG, Watson DI. Prospective randomized controlled trial of argon plasma coagulation ablation vs. endoscopic surveillance of patients with Barrett's esophagus after antireflux surgery. Gastrointest Endosc 2004 Jan;59(1):1-7 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/14722539.
Assigned to
User:Mark.schoeman
Topic area
Guidelines:Barrett's
Clinical question
Form
Form:Critical appraisal


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