Critical appraisal:Admad N Z, Ahmed A 2010 2

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Critical Appraisal

Article being appraised

Admad N Z, Ahmed A. A meta-analysis of randomized controlled trials comparing methylene blue-directed biopsies with random biopsies in the surveillance of Barrett's esophagus. Esophagus 2010 [cited 2012 Dec 19];7:4 (207-213) Abstract available at http://www.embase.com.ezproxy2.library.usyd.edu.au/search/results?subaction=viewrecord&id=L361449159&from=savedclipboard&L361449159.


Applicable clinical question

Key Facts

Study Design

systematic review — randomised trials

Number of Patients:

213



Evidence ratings

Level of evidence

I

Risk of bias
Moderate risk of bias Comments: Please replace this text and include any additional comments in regards to your quality rating

Risk of bias assessment: systematic review

Studies included in the review
Was an adequate search strategy used?
Very thorough – included appropriate search terms and databases
Were the inclusion criteria appropriate and applied in an unbiased way?
Yes – pre-specified inclusion criteria applied independently by two people
Were the studies assessed for quality (relating to the minimisation of biases)?
Yes – appropriate quality issues were assessed independently by two people
Were the characteristics and results of individual studies appropriately summarised?
Yes – summary descriptive tables of subjects, interventions, outcomes etc are provided and estimates of treatment effect displayed
The following questions are only relevant for systematic reviews that pooled data
Were the methods used for pooling the data appropriate?
Yes
If there was heterogeneity, were sources of heterogeneity explored?
Some attempt was made
Size of effect
2 Reason for decision: Please replace this text and briefly describe the reasons for your rating
Relevance of evidence
2 Additional comments: Please replace this text and briefly describe the reasons for your rating
Result of appraisal

Jutta's tick icon.png Included




Completed by

Dr Eric Y Lee BSc(Med) MBBS Hons FRACP


Jutta's tick icon.png This appraisal has been completed.


Article
Admad N Z, Ahmed A. A meta-analysis of randomized controlled trials comparing methylene blue-directed biopsies with random biopsies in the surveillance of Barrett's esophagus. Esophagus 2010 [cited 2012 Dec 19];7:4 (207-213) Abstract available at http://www.embase.com.ezproxy2.library.usyd.edu.au/search/results?subaction=viewrecord&id=L361449159&from=savedclipboard&L361449159.
Assigned to
User:Eric.lee
Topic area
Guidelines:Barrett's
Clinical question
Form
Form:Critical appraisal


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