Critical appraisal:Al-Absi E, Farrokhyar F, Sharma R, Whelan K, Corbett T, Patel M, et al 2010 6

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Critical Appraisal

Article being appraised

Al-Absi E, Farrokhyar F, Sharma R, Whelan K, Corbett T, Patel M, et al. A systematic review and meta-analysis of oncologic outcomes of pre- versus postoperative radiation in localized resectable soft-tissue sarcoma. Ann Surg Oncol 2010 May;17(5):1367-74 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/20217260.


Applicable clinical question

Key Facts

Study Design

systematic review — one randomised and four retrospective studies

Number of Patients:

1098


Includes an economic evaluation

no

Evidence ratings

Level of evidence

III-2

Risk of bias
Low risk of bias Comments: Despite the limitations of this systematic review, the results represent the best data currently available.

Risk of bias assessment: systematic review

Studies included in the review
Was an adequate search strategy used?
Very thorough – included appropriate search terms and databases
Were the inclusion criteria appropriate and applied in an unbiased way?
Yes – pre-specified inclusion criteria applied independently by two people
Were the studies assessed for quality (relating to the minimisation of biases)?
Yes – appropriate quality issues were assessed independently by two people
Were the characteristics and results of individual studies appropriately summarised?
Yes – summary descriptive tables of subjects, interventions, outcomes etc are provided and estimates of treatment effect displayed
The following questions are only relevant for systematic reviews that pooled data
Were the methods used for pooling the data appropriate?
Yes
If there was heterogeneity, were sources of heterogeneity explored?
Yes
Size of effect
2 Reason for decision: Please replace this text and briefly describe the reasons for your rating
Relevance of evidence
1 Additional comments: This study includes patient-relevant clinical outcomes such as the risk of local recurrence and average survival rate.
Result of appraisal

Jutta's tick icon.png Included




Completed by

Dr Julie Chu


Jutta's tick icon.png This appraisal has been completed.


Article
Al-Absi E, Farrokhyar F, Sharma R, Whelan K, Corbett T, Patel M, et al. A systematic review and meta-analysis of oncologic outcomes of pre- versus postoperative radiation in localized resectable soft-tissue sarcoma. Ann Surg Oncol 2010 May;17(5):1367-74 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/20217260.
Assigned to
User:Marcus.foo
Topic area
Guidelines:Sarcoma
Clinical question
Form
Form:Critical appraisal


Section below only relevant for Cancer Council Project Officer

Edit appraisal assignment