Critical appraisal:Alektiar KM, Brennan MF, Healey JH, Singer S 2008 3

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Critical Appraisal

Article being appraised

Alektiar KM, Brennan MF, Healey JH, Singer S. Impact of intensity-modulated radiation therapy on local control in primary soft-tissue sarcoma of the extremity. J Clin Oncol 2008 Jul 10;26(20):3440-4 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/18612160.


Applicable clinical question

Key Facts

Study Design

case series

Number of Patients:

41


Includes an economic evaluation

no

Evidence ratings

Level of evidence

IV

Risk of bias
High risk of bias Comments: In addition to local control rate, distant-metastasis-free survival and overall survival rate, toxicities (wound complications, fracture, joint stiffness, oedema and nerve damage) were also reported which were mainly G2 or less.

Risk of bias assessment: case series

Subject selection:
Highly selected or not described (e.g. single-institution study)
Were the outcome measures blind to pre/post-intervention?
No or not described
Follow-up complete and all patients included in the analysis?
No or not described
Size of effect
4 Reason for decision: Please replace this text and briefly describe the reasons for your rating
Relevance of evidence
5 Additional comments:
Result of appraisal

Jutta's tick icon.png Included




Completed by

Dr Julie Chu


Jutta's tick icon.png This appraisal has been completed.


Article
Alektiar KM, Brennan MF, Healey JH, Singer S. Impact of intensity-modulated radiation therapy on local control in primary soft-tissue sarcoma of the extremity. J Clin Oncol 2008 Jul 10;26(20):3440-4 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/18612160.
Assigned to
User:Julie.chu
Topic area
Guidelines:Sarcoma
Clinical question
Form
Form:Critical appraisal


Section below only relevant for Cancer Council Project Officer

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