Critical appraisal:Alektiar KM, Brennan MF, Singer S 2011 4

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Critical Appraisal

Article being appraised

Alektiar KM, Brennan MF, Singer S. Local control comparison of adjuvant brachytherapy to intensity-modulated radiotherapy in primary high-grade sarcoma of the extremity. Cancer 2011 Jul 15;117(14):3229-34 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/21264834.


Applicable clinical question

Key Facts

Study Design

cohort study

Number of Patients:

134


Includes an economic evaluation

no

Evidence ratings

Level of evidence

III-2

Risk of bias
High risk of bias Comments:

Risk of bias assessment: cohort study

Subject selection
"New technology" group
No response
Comparison group
No response
Comparability of groups on demographic characteristics and clinical features
No response
Measurement of outcomes
Outcome measures blind to technology used
No response
Same method of measurement used across comparison groups
No response
Completeness of follow-up
Was follow-up complete and were all patients included in the analysis?
No response
Size of effect
2 Reason for decision: IMRT found to be an independent predictor of improved local control on multivariate analysis with a p value of 0.04
Relevance of evidence
1 Additional comments: Patient-relevant clinical outcomes such as local control and wound complications.
Result of appraisal

Jutta's tick icon.png Included




Completed by

Dr Julie Chu


Jutta's tick icon.png This appraisal has been completed.


Article
Alektiar KM, Brennan MF, Singer S. Local control comparison of adjuvant brachytherapy to intensity-modulated radiotherapy in primary high-grade sarcoma of the extremity. Cancer 2011 Jul 15;117(14):3229-34 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/21264834.
Assigned to
User:Marcus.foo
Topic area
Guidelines:Sarcoma
Clinical question
Form
Form:Critical appraisal


Section below only relevant for Cancer Council Project Officer

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