Critical appraisal:Alektiar KM, Hong L, Brennan MF, Della-Biancia C, Singer S 2007 3

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Critical Appraisal

Article being appraised

Alektiar KM, Hong L, Brennan MF, Della-Biancia C, Singer S. Intensity modulated radiation therapy for primary soft tissue sarcoma of the extremity: preliminary results. Int J Radiat Oncol Biol Phys 2007 Jun 1;68(2):458-64 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/17363186.


Applicable clinical question

Key Facts

Study Design

case series

Number of Patients:

31


Includes an economic evaluation

no

Evidence ratings

Level of evidence

IV

Risk of bias
High risk of bias Comments: This is a a single institutional case series evaluating IMRT either preoperatively or post operatively in the management of primary soft tissue sarcoma of the extremities. Local control rates were excellent and toxicity was favourable.

Risk of bias assessment: case series

Subject selection:
Highly selected or not described (e.g. single-institution study)
Were the outcome measures blind to pre/post-intervention?
No or not described
Follow-up complete and all patients included in the analysis?
No or not described
Size of effect
4 Reason for decision: Please replace this text and briefly describe the reasons for your rating
Relevance of evidence
1 Additional comments: Examined local control and toxicity.
Result of appraisal

Jutta's tick icon.png Included




Completed by

Dr Sarat Chander FRANZCR


Jutta's tick icon.png This appraisal has been completed.


Article
Alektiar KM, Hong L, Brennan MF, Della-Biancia C, Singer S. Intensity modulated radiation therapy for primary soft tissue sarcoma of the extremity: preliminary results. Int J Radiat Oncol Biol Phys 2007 Jun 1;68(2):458-64 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/17363186.
Assigned to
User:Sarat.chander
Topic area
Guidelines:Sarcoma
Clinical question
Form
Form:Critical appraisal


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