Critical appraisal:Alektiar KM, Hu K, Anderson L, Brennan MF, Harrison LB 2000

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Critical Appraisal

Article being appraised

Alektiar KM, Hu K, Anderson L, Brennan MF, Harrison LB. High-dose-rate intraoperative radiation therapy (HDR-IORT) for retroperitoneal sarcomas. Int J Radiat Oncol Biol Phys 2000 Apr 1;47(1):157-63 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/10758318.


Applicable clinical question

Key Facts

Study Design

case series

Number of Patients:

32


Includes an economic evaluation

no

Evidence ratings

Level of evidence

IV

Risk of bias
High risk of bias Comments: Prospective Case series of 32 retroperitoneal sarcomas, treated with HDR _ IORT with surgery, usually combined with EBRT.

Risk of bias assessment: case series

Subject selection:
Highly selected or not described (e.g. single-institution study)
Were the outcome measures blind to pre/post-intervention?
No or not described
Follow-up complete and all patients included in the analysis?
Yes (follow-up >95%)
Size of effect
5 Reason for decision: Non compartive single arm prospective case series.
Relevance of evidence
1 Additional comments: Local control, survival and complications have been assessed.
Result of appraisal

Jutta's tick icon.png Included


Reason for decision

Deals with Radiation for Retroperitoneal Sarcomas, which is outside the scope of this guideline.


Completed by

Dr Sarat Chander FRANZCR


Jutta's tick icon.png This appraisal has been completed.


Article
Alektiar KM, Hu K, Anderson L, Brennan MF, Harrison LB. High-dose-rate intraoperative radiation therapy (HDR-IORT) for retroperitoneal sarcomas. Int J Radiat Oncol Biol Phys 2000 Apr 1;47(1):157-63 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/10758318.
Assigned to
User:Sarat.chander
Topic area
Guidelines:Sarcoma
Clinical question
Form
Form:Critical appraisal


Section below only relevant for Cancer Council Project Officer

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