Critical appraisal:Alektiar KM, McKee AB, Jacobs JM, McKee BJ, Healey JH, Brennan MF 2002

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Critical Appraisal

Article being appraised

Alektiar KM, McKee AB, Jacobs JM, McKee BJ, Healey JH, Brennan MF. Outcome of primary soft tissue sarcoma of the knee and elbow. Int J Radiat Oncol Biol Phys 2002 Sep 1;54(1):163-9 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/12182987.


Applicable clinical question

Key Facts

Study Design

cohort study

Number of Patients:

86


Includes an economic evaluation

no

Evidence ratings

Level of evidence

III-2

Risk of bias
Moderate risk of bias Comments: Please replace this text and include any additional comments in regards to your quality rating

Risk of bias assessment: cohort study

Subject selection
"New technology" group
No response
Comparison group
No response
Comparability of groups on demographic characteristics and clinical features
No response
Measurement of outcomes
Outcome measures blind to technology used
No response
Same method of measurement used across comparison groups
No response
Completeness of follow-up
Was follow-up complete and were all patients included in the analysis?
No response
Size of effect
2 Reason for decision: No difference in LC or most morbidity outcomes, except joint stiffness
Relevance of evidence
1 Additional comments: This retrospective study specifically looked at STS in elbow and knee. No difference in local recurrence was seen though more patients in the RT group had deep and higher grade tumours. RT however was associated with higher risks of joint stiffness. Other morbidity, however was similar in terms of wound complications, bone fracture & nerve damage.
Result of appraisal

Jutta's tick icon.png Included




Completed by

Dr Marcus Foo FRANZCR


Jutta's tick icon.png This appraisal has been completed.


Article
Alektiar KM, McKee AB, Jacobs JM, McKee BJ, Healey JH, Brennan MF. Outcome of primary soft tissue sarcoma of the knee and elbow. Int J Radiat Oncol Biol Phys 2002 Sep 1;54(1):163-9 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/12182987.
Assigned to
User:Marcus.foo
Topic area
Guidelines:Sarcoma
Clinical question
Form
Form:Critical appraisal


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