Critical appraisal:Alektiar KM, Zelefsky MJ, Brennan MF 2000

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Critical Appraisal

Article being appraised

Alektiar KM, Zelefsky MJ, Brennan MF. Morbidity of adjuvant brachytherapy in soft tissue sarcoma of the extremity and superficial trunk. Int J Radiat Oncol Biol Phys 2000 Jul 15;47(5):1273-9 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/10889381.


Applicable clinical question

Key Facts

Study Design

randomised controlled trial

Number of Patients:

164


Includes an economic evaluation

no

Evidence ratings

Level of evidence

I

Risk of bias
High risk of bias Comments: Please replace this text and include any additional comments in regards to your quality rating

Risk of bias assessment: randomised controlled trial

Was the trial double-blinded?
Trial was double-blinded but may have limitations (eg method of blinding inappropriate, tablet vs injection with no double-dummy, different treatment schedules, side-effects may unblind)

or
single-blinded (eg outcomes assessed blind, objective outcomes, no revealing side-effects).

Was the treatment allocation schedule concealed?
No concealment or unclear (e.g. no approach described, open randomisation lists, person doing recruitment tossing a coin).
Were all randomised participants included in the analysis?
No exclusions or survival analysis used with all subjects included (>95% follow-up for all groups).
The field below is not considered when calculating the risk of bias rating
How was the allocation schedule generated?
Inadequate or not reported
Size of effect
4 Reason for decision: Please replace this text and briefly describe the reasons for your rating
Relevance of evidence
1 Additional comments: Please replace this text and briefly describe the reasons for your rating
Result of appraisal

Jutta's tick icon.png Included




Completed by

Dr Sarat Chander FRANZCR


Jutta's tick icon.png This appraisal has been completed.


Article
Alektiar KM, Zelefsky MJ, Brennan MF. Morbidity of adjuvant brachytherapy in soft tissue sarcoma of the extremity and superficial trunk. Int J Radiat Oncol Biol Phys 2000 Jul 15;47(5):1273-9 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/10889381.
Assigned to
User:Sarat.chander
Topic area
Guidelines:Sarcoma
Clinical question
Form
Form:Critical appraisal


Section below only relevant for Cancer Council Project Officer

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