Critical appraisal:Alexandre L, Clark AB, Cheong E, Lewis MP, Hart AR 2012

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Critical Appraisal

Article being appraised

Alexandre L, Clark AB, Cheong E, Lewis MP, Hart AR. Systematic review: potential preventive effects of statins against oesophageal adenocarcinoma. Aliment Pharmacol Ther 2012 Aug;36(4):301-11 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/22716127.


Applicable clinical question

Key Facts

Study Design

systematic review — Non-randomised only

Number of Patients:

35214


Includes an economic evaluation

no

Evidence ratings

Level of evidence

III-3

Risk of bias
High risk of bias Comments: not based on RCT's. No good evidence underpinning this question

Risk of bias assessment: systematic review

Studies included in the review
Was an adequate search strategy used?
Adequate – search terms and/or choice of databases could have been improved upon
Were the inclusion criteria appropriate and applied in an unbiased way?
Yes – pre-specified inclusion criteria applied independently by two people
Were the studies assessed for quality (relating to the minimisation of biases)?
Yes – appropriate quality issues were assessed independently by two people
Were the characteristics and results of individual studies appropriately summarised?
Yes – summary descriptive tables of subjects, interventions, outcomes etc are provided and estimates of treatment effect displayed
The following questions are only relevant for systematic reviews that pooled data
Were the methods used for pooling the data appropriate?
Yes
If there was heterogeneity, were sources of heterogeneity explored?
Some attempt was made
Size of effect
4 Reason for decision: metanalysis but the data underpinning this is poor
Relevance of evidence
1 Additional comments: Please replace this text and briefly describe the reasons for your rating
Result of appraisal

Jutta's tick icon.png Included




Completed by

Professor David Watson MBBS, MD, FRACS


Jutta's tick icon.png This appraisal has been completed.


Article
Alexandre L, Clark AB, Cheong E, Lewis MP, Hart AR. Systematic review: potential preventive effects of statins against oesophageal adenocarcinoma. Aliment Pharmacol Ther 2012 Aug;36(4):301-11 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/22716127.
Assigned to
User:David.watson
Topic area
Guidelines:Barrett's
Clinical question
Form
Form:Critical appraisal


Section below only relevant for Cancer Council Project Officer

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