Critical appraisal:Alexandropoulou K, van Vlymen J, Reid F, Poullis A, Kang JY 2013

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Critical Appraisal

Article being appraised

Alexandropoulou K, van Vlymen J, Reid F, Poullis A, Kang JY. Temporal trends of Barrett's oesophagus and gastro-oesophageal reflux and related oesophageal cancer over a 10-year period in England and Wales and associated proton pump inhibitor and H2RA prescriptions: a GPRD study. Eur J Gastroenterol Hepatol 2013 Jan;25(1):15-21 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/23022985.


Applicable clinical question

Key Facts

Study Design

prevalence and incidence study

Number of Patients:

Not applicable



Evidence ratings

Risk of bias
Low risk of bias Comments: Please replace this text and include any additional comments in regards to your quality rating

Risk of bias assessment: prevalence and incidence study

Source population of patients
Selected group (multiple institutions)
Subject (sample) selection
Representative of eligible patients (consecutive or random sample e.g. states all patients recruited in given time frame)
Measurement of condition
Objective and reliable (based on registry or other equivalent source)
Follow-up complete and all patients included in the analysis?
Yes (follow-up >95%)
Result of appraisal

Jutta's tick icon.png Included



Comments

There were 5860 patients with BO. The incidence of BO increased from 0.11 to 0.24/1000 men and from 0.06 to 0.11/1000 women. There were 69 incident OCs in patients with BOs. The cumulative incidence of OC was 3.00/1000 BO patient years.

Completed by

Associate Professor Freddy Sitas


Jutta's tick icon.png This appraisal has been completed.


Article
Alexandropoulou K, van Vlymen J, Reid F, Poullis A, Kang JY. Temporal trends of Barrett's oesophagus and gastro-oesophageal reflux and related oesophageal cancer over a 10-year period in England and Wales and associated proton pump inhibitor and H2RA prescriptions: a GPRD study. Eur J Gastroenterol Hepatol 2013 Jan;25(1):15-21 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/23022985.
Assigned to
User:Freddy.sitas
Topic area
Guidelines:Barrett's/Natural history
Clinical question
Form
Form:Critical appraisal


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