Critical appraisal:Anderson RA, Weddell A, Spoudeas HA, Douglas C, Shalet SM, Levitt G, et al 2008

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Critical Appraisal

Article being appraised

Anderson RA, Weddell A, Spoudeas HA, Douglas C, Shalet SM, Levitt G, et al. Do doctors discuss fertility issues before they treat young patients with cancer? Hum Reprod 2008 Oct;23(10):2246-51 Available from: http://www.ncbi.nlm.nih.gov/pubmed/18614615.


Applicable clinical question

Key Facts

Study Design

cross sectional study

Study aims:

Assessment of UK practice relating to information provision about the effects of cancer treatment on fertility and options for fertility preservation for children diagnosed with cancer

Number of Patients:

1030

Reported outcome(s):

Effect of cancer treatment on fertility discussed with 63% of patients.
Of these, 61% were at high or medium risk of fertility problems.
Discussions more common for boys than girls - commonest reason for discussion not occurring was young age.

Results of outcome(s):

83% of post-pubertal boys assessed as high/medium risk of infertility referred for semen cryopreservation. 39% of those in early puberty assessed as high/medium risk of infertility referred for semen cryopreservation
1% girls referred to an assisted conception unit.

Comments on results:

Current guidelines are followed for older boys
There is a need for fertility preservation techniques for girls and younger boys.

Includes an economic evaluation

no

Evidence ratings

Level of evidence

IV

Risk of bias
Moderate risk of bias Comments:
Result of appraisal

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Completed by

Dr Jessica Harris

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Article
Anderson RA, Weddell A, Spoudeas HA, Douglas C, Shalet SM, Levitt G, et al. Do doctors discuss fertility issues before they treat young patients with cancer? Hum Reprod 2008 Oct;23(10):2246-51 Available from: http://www.ncbi.nlm.nih.gov/pubmed/18614615.
Assigned to
User:Marianne.phillips
Topic area
Guidelines:COSA:Cancer fertility preservation guidelines/Discussing risk
Clinical question
Form
Form:Critical appraisal


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