Critical appraisal:Antognoni P, Cerizza L, Vavassori V, Molteni M, Garavello M, Salvadore M, et al 1992 2

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Critical Appraisal

Article being appraised

Antognoni P, Cerizza L, Vavassori V, Molteni M, Garavello M, Salvadore M, et al. Postoperative radiation therapy for adult soft tissue sarcomas: a retrospective study. Ann Oncol 1992 Apr;3 Suppl 2:S103-6 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/1622849.


Applicable clinical question

Key Facts

Study Design

case series

Number of Patients:

81


Includes an economic evaluation

no

Evidence ratings

Level of evidence

IV

Risk of bias
High risk of bias Comments: Please replace this text and include any additional comments in regards to your quality rating

Risk of bias assessment: case series

Subject selection:
Highly selected or not described (e.g. single-institution study)
Were the outcome measures blind to pre/post-intervention?
No or not described
Follow-up complete and all patients included in the analysis?
No or not described
Size of effect
5 Reason for decision: All patients treated with post-op RT. No comparison group.
Relevance of evidence
1 Additional comments: Heterogeneous group of histologies (incl. rhabdomyosarcoma, DFSP & angiosarcoma), extent of surgery, sites (majority extremity, but includes H&N, pelvis, trunk)

This report had higher local recurrences when compared with other series. This may be due to the fact that almost 38% of new referrals had R1/2 resections, prior to RT.

Result of appraisal

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Completed by

Dr Marcus Foo FRANZCR


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Article
Antognoni P, Cerizza L, Vavassori V, Molteni M, Garavello M, Salvadore M, et al. Postoperative radiation therapy for adult soft tissue sarcomas: a retrospective study. Ann Oncol 1992 Apr;3 Suppl 2:S103-6 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/1622849.
Assigned to
User:Marcus.foo
Topic area
Guidelines:Sarcoma
Clinical question
Form
Form:Critical appraisal


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