Critical appraisal:Ares C, Hug EB, Lomax AJ, Bolsi A, Timmermann B, Rutz HP, et al 2009

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Critical Appraisal

Article being appraised

Ares C, Hug EB, Lomax AJ, Bolsi A, Timmermann B, Rutz HP, et al. Effectiveness and safety of spot scanning proton radiation therapy for chordomas and chondrosarcomas of the skull base: first long-term report. Int J Radiat Oncol Biol Phys 2009 Nov 15;75(4):1111-8 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/19386442.


Applicable clinical question

Key Facts

Study Design

case series

Number of Patients:

64


Includes an economic evaluation

no

Evidence ratings

Level of evidence

IV

Risk of bias
High risk of bias Comments: Please replace this text and include any additional comments in regards to your quality rating

Risk of bias assessment: case series

Subject selection:
Highly selected or not described (e.g. single-institution study)
Were the outcome measures blind to pre/post-intervention?
No or not described
Follow-up complete and all patients included in the analysis?
Yes (follow-up >95%)
Size of effect
5 Reason for decision:
Relevance of evidence
1 Additional comments: 5 year local control 81% for Chordomas and 94% for Chondrosarcomas
Result of appraisal

Jutta's tick icon.png Included




Completed by

Dr Sarat Chander FRANZCR


Jutta's tick icon.png This appraisal has been completed.


Article
Ares C, Hug EB, Lomax AJ, Bolsi A, Timmermann B, Rutz HP, et al. Effectiveness and safety of spot scanning proton radiation therapy for chordomas and chondrosarcomas of the skull base: first long-term report. Int J Radiat Oncol Biol Phys 2009 Nov 15;75(4):1111-8 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/19386442.
Assigned to
User:Sarat.chander
Topic area
Guidelines:Sarcoma
Clinical question
Form
Form:Critical appraisal


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