Critical appraisal:Babayev SN, Arslan E, Kogan S, Moy F, Oktay K 2013
- Babayev SN, Arslan E, Kogan S, Moy F, Oktay K. Evaluation of ovarian and testicular tissue cryopreservation in children undergoing gonadotoxic therapies. J Assist Reprod Genet 2013 Jan;30(1):3-9 Available from: http://www.ncbi.nlm.nih.gov/pubmed/23242649.
- Assigned to
- Topic area
- Guidelines:COSA:Cancer fertility preservation guidelines/Options for treatment
- Clinical question
Section below only relevant for Cancer Council Project Officer
Babayev SN, Arslan E, Kogan S, Moy F, Oktay K. Evaluation of ovarian and testicular tissue cryopreservation in children undergoing gonadotoxic therapies. J Assist Reprod Genet 2013 Jan;30(1):3-9 Available from: http://www.ncbi.nlm.nih.gov/pubmed/23242649.
- In male cancer patients does the use of cryopreserved testicular tissue result in pregnancy and live birth? Is there any evidence of harm from the harvesting procedure?
To investigate the short term safety of unilateral testis biopsy in male children with cancer and haematological disorders about to receive gonadotoxic therapies.
N=4 of these had cancer
Blood loss, operative and anaesthetic times and surgery adverse events.
There were no data on subsequent fertility, reproductive or other aspects ofhealth
No data on histology. Most of the biopsy was just frozen
Minimal blood loss.
No complications during hospitalisation.
Readily acknowledge that testis biopsy for stem cell cryopreservation and later use by patient is experimental.
There is no data on such use so success cannot be guaranteed
Spoke of the strategic bundling of medically indicated procedures (eg insertion of IV catheters for later treatment use) with gonadal tissue harvesting can potentially reduce risks, cost, and inconvenience.
|High risk of bias||Comments: The numbers are very small.
There is no statement about how many parents were approached and declined to have biopsy/storage, thus there is a risk of selection bias though it does not appear this information would in any way affect the very limited scope of safety endpoints.
|5||Reason for decision:|
This study evaluates the collection not use of cryopreserved testicular tissue - it is included only as it addressed consequences of the harvesting procedure (second part of the question)