Critical appraisal:Badreddine RJ, Prasad GA, Wang KK, Song LM, Buttar NS, Dunagan KT, et al 2010

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Critical Appraisal

Article being appraised

Badreddine RJ, Prasad GA, Wang KK, Song LM, Buttar NS, Dunagan KT, et al. Prevalence and predictors of recurrent neoplasia after ablation of Barrett's esophagus. Gastrointest Endosc 2010 Apr;71(4):697-703 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/19959164.


Applicable clinical question

Key Facts

Study Design

case series

Number of Patients:

261


Includes an economic evaluation

no

Evidence ratings

Level of evidence

IV

Risk of bias
High risk of bias Comments: about 17% (44pts) lost to f/u

Risk of bias assessment: case series

Subject selection:
Highly selected or not described (e.g. single-institution study)
Were the outcome measures blind to pre/post-intervention?
No, but objective measures used
Follow-up complete and all patients included in the analysis?
Reasonable (follow-up >80%)
Size of effect
5 Reason for decision: no comparitor
Relevance of evidence
2 Additional comments: appears signif long term effect on LGD. This paper is a mixture of LGD, HGD and cancer. Also, many had EMR (more than half) so really a reflection of long term outcomes for PDT +/- EMR
Result of appraisal

Jutta's tick icon.png Included




Completed by

Dr Andrew Taylor MBBS MD FRACP


Jutta's tick icon.png This appraisal has been completed.


Article
Badreddine RJ, Prasad GA, Wang KK, Song LM, Buttar NS, Dunagan KT, et al. Prevalence and predictors of recurrent neoplasia after ablation of Barrett's esophagus. Gastrointest Endosc 2010 Apr;71(4):697-703 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/19959164.
Assigned to
User:Andrew.taylor
Topic area
Guidelines:Barrett's
Clinical question
Form
Form:Critical appraisal


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