Critical appraisal:Bass AJ, Meyerhardt JA, Chan JA, Giovannucci EL, Fuchs CS 2008 2

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Risk of bias assessment: cohort study

Subject selection
"New technology" group
Selected group
Comparison group
Selected group
Comparability of groups on demographic characteristics and clinical features
Measurement of outcomes
Outcome measures blind to technology used
No, but objective measures used
Same method of measurement used across comparison groups
Completeness of follow-up
Was follow-up complete and were all patients included in the analysis?
Yes (follow-up >95%) or survival analysis using all patients
Overall risk of bias
Moderate risk of bias Additional comments: NHS cohort was already used in another study (Wei ?)

Comparability demographics: Participants with and without family history did not differ substantially by age, BMI, smoking status, or histologic grade of their tumor. However, participants with a family history were less likely to have metastatic (stage IV) disease or primary tumor location in the rectum and were more likely to have undergone prior screening endoscopy

FU: Mortality follow-up was more then 98% complete

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Bass AJ, Meyerhardt JA, Chan JA, Giovannucci EL, Fuchs CS. Family history and survival after colorectal cancer diagnosis. Cancer 2008 Mar 15;112(6):1222-9 Available from:
Assigned to
Topic area
Guidelines:Colorectal cancer
Clinical question
Form:Quality appraisal cohort

Section below only relevant for Cancer Council Project Officer

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