Critical appraisal:Bass AJ, Meyerhardt JA, Chan JA, Giovannucci EL, Fuchs CS 2008 2

Risk of bias assessment: cohort study

Subject selection

"New technology" group

Selected group

Comparison group

Selected group

Comparability of groups on demographic characteristics and clinical features

Comparable

Measurement of outcomes

Outcome measures blind to technology used

No, but objective measures used

Same method of measurement used across comparison groups

Yes

Completeness of follow-up

Was follow-up complete and were all patients included in the analysis?

Yes (follow-up >95%) or survival analysis using all patients

Overall risk of bias

Moderate risk of bias

Additional comments: NHS cohort was already used in another study (Wei ?) Comparability demographics: Participants with and without family history did not differ substantially by age, BMI, smoking status, or histologic grade of their tumor. However, participants with a family history were less likely to have metastatic (stage IV) disease or primary tumor location in the rectum and were more likely to have undergone prior screening endoscopy FU: Mortality follow-up was more then 98% complete

This appraisal has been completed.

Article

Bass AJ, Meyerhardt JA, Chan JA, Giovannucci EL, Fuchs CS. Family history and survival after colorectal cancer diagnosis. Cancer 2008 Mar 15;112(6):1222-9 Available from: http://www.ncbi.nlm.nih.gov/pubmed/18219663.

Assigned to

User:Verity.chadwick

Topic area

Guidelines:Colorectal cancer

Clinical question

• FHS2: What is the strength of association between family history and colorectal cancer risk and how do these associations vary by, number of affected relatives and degree of relatedness and age and sex of affected relatives and by the age and sex of the at-risk person?

Form

Form:Quality appraisal cohort

Section below only relevant for Cancer Council Project Officer

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