Critical appraisal:Bhat S, Coleman HG, Yousef F, Johnston BT, McManus DT, Gavin AT, et al 2011 2

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Critical Appraisal

Article being appraised

Bhat S, Coleman HG, Yousef F, Johnston BT, McManus DT, Gavin AT, et al. Risk of malignant progression in Barrett's esophagus patients: results from a large population-based study. J Natl Cancer Inst 2011 Jul 6;103(13):1049-57 Available from: http://www.ncbi.nlm.nih.gov/pubmed/21680910.


Applicable clinical question

Key Facts

Study Design

prevalence and incidence study

Number of Patients:

2840


Includes an economic evaluation

no

Evidence ratings

Risk of bias
High risk of bias Comments: Large number but limited follow up as it was a pathology based study (follow up at the discretion of the clinician and endoscopic visualisation in the absence of biopsies not known), excluded prevelant cases

Risk of bias assessment: prevalence and incidence study

Source population of patients
Selected group (multiple institutions)
Subject (sample) selection
Highly selected (selection at clinician's discretion regardless of whether sample consecutive), unclear or not described
Measurement of condition
Objective and reliable (based on registry or other equivalent source)
Follow-up complete and all patients included in the analysis?
Yes (follow-up >95%)
Result of appraisal

Jutta's tick icon.png Included



Comments

ow rate of progression to EAC, LGD was associated with greater risk of progression (1.4% py vs 0.17% pb HR 5.67, 95% CI 3.77 - 8.53), higher rate of progression for SIM at index endoscopy than with CLE (0.38% vs 0.07% py HR 3.54 95% CI 2.09-6.0), and higher in males (0.28% vs 0.13% py HR 2.11 95% CI 1.41-3.16)

Completed by

Dr Henry To


Jutta's tick icon.png This appraisal has been completed.


Article
Bhat S, Coleman HG, Yousef F, Johnston BT, McManus DT, Gavin AT, et al. Risk of malignant progression in Barrett's esophagus patients: results from a large population-based study. J Natl Cancer Inst 2011 Jul 6;103(13):1049-57 Available from: http://www.ncbi.nlm.nih.gov/pubmed/21680910.
Assigned to
User:David.whiteman
Topic area
Guidelines:Barrett's
Clinical question
Form
Form:Critical appraisal


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