Critical appraisal:Bhat S, Coleman HG, Yousef F, Johnston BT, McManus DT, Gavin AT, et al 2011 4
From Cancer Guidelines Wiki
Critical Appraisal
Article being appraised
Bhat S, Coleman HG, Yousef F, Johnston BT, McManus DT, Gavin AT, et al. Risk of malignant progression in Barrett's esophagus patients: results from a large population-based study. J Natl Cancer Inst 2011 Jul 6;103(13):1049-57 Available from: http://www.ncbi.nlm.nih.gov/pubmed/21680910.
Applicable clinical question
Key Facts
Study Design
prevalence and incidence study
Number of Patients:
2840
Includes an economic evaluation
no
Evidence ratings
Risk of bias
| High risk of bias | Comments: Large number but limited follow up as it was a pathology based study (follow up at the discretion of the clinician and endoscopic visualisation in the absence of biopsies not known), excluded prevelant cases |
Result of appraisal
Included
Comments
Completed by
This appraisal has been completed.
- Article
- Bhat S, Coleman HG, Yousef F, Johnston BT, McManus DT, Gavin AT, et al. Risk of malignant progression in Barrett's esophagus patients: results from a large population-based study. J Natl Cancer Inst 2011 Jul 6;103(13):1049-57 Available from: http://www.ncbi.nlm.nih.gov/pubmed/21680910.
- Assigned to
- User:Philip.craig
- Topic area
- Guidelines:Barrett's
- Clinical question
Section below only relevant for Cancer Council Project Officer
ow rate of progression to EAC, LGD was associated with greater risk of progression (1.4% py vs 0.17% pb HR 5.67, 95% CI 3.77 - 8.53), higher rate of progression for SIM at index endoscopy than with CLE (0.38% vs 0.07% py HR 3.54 95% CI 2.09-6.0), and higher in males (0.28% vs 0.13% py HR 2.11 95% CI 1.41-3.16)