Critical appraisal:Byrom L, Olsen CM, Knight L, Khosrotehrani K, Green AC 2015

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Critical Appraisal

Article being appraised

Byrom L, Olsen CM, Knight L, Khosrotehrani K, Green AC. Does pregnancy after a diagnosis of melanoma affect prognosis? Systematic review and meta-analysis. Dermatol Surg 2015 Aug;41(8):875-82 Available from: http://www.ncbi.nlm.nih.gov/pubmed/26177116.


Applicable clinical question

Key Facts

Study Design

systematic review — Both retrospective clinical cohorts (n=3) and population cohorts (n=2)

Study aims:

To evaluate the effect of a subsequent pregnancy on cause-specific death and recurrence of melanomas

Number of Patients:

11369

Reported outcome(s):

Melanoma mortality and recurrence

Results of outcome(s):

There was no significant effect of subsequent pregnancy on melanoma mortality after 11 to 20 years of follow-up (pooled hazard ratio, 0.81; 95% confidence interval, 0.60–1.09) and no significant differences in melanoma recurrence.

Includes an economic evaluation

no

Evidence ratings

Level of evidence

III-3

Risk of bias
Low risk of bias Comments:
Result of appraisal

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Completed by

Dr Stefan C. Kane MBBS BA BMedSc FRANZCOG CMFM DDU(O&G)

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Article
Byrom L, Olsen CM, Knight L, Khosrotehrani K, Green AC. Does pregnancy after a diagnosis of melanoma affect prognosis? Systematic review and meta-analysis. Dermatol Surg 2015 Aug;41(8):875-82 Available from: http://www.ncbi.nlm.nih.gov/pubmed/26177116.
Assigned to
User:Stefan.kane
Topic area
Guidelines:COSA:Cancer fertility preservation guidelines/Preconception assessment for cancer survivors
Clinical question
Form
Form:Critical appraisal


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