Critical appraisal:Cameron KE, Kole MB, Sammel MD, Ginsberg JP, Gosiengfiao Y, Mersereau JE, et al 2018

From Cancer Guidelines Wiki

Critical Appraisal

Article being appraised

Cameron KE, Kole MB, Sammel MD, Ginsberg JP, Gosiengfiao Y, Mersereau JE, et al. Acute Menopausal Symptoms in Young Cancer Survivors Immediately following Chemotherapy. Oncology 2018;94(4):200-206 Available from: http://www.ncbi.nlm.nih.gov/pubmed/29393227.


Applicable clinical question

Key Facts

Study Design

cohort study

Study aims:

to determine the effect on AMH and menopausal symptoms after chemotherapy.

Number of Patients:

124

Reported outcome(s):

decrease in serum AMH 1 month post cessation of chemotherapy

Results of outcome(s):

Levels of AMH decreased after cancer therapy, and lower levels were associated with an increase in prevalence of many symptoms. The post-treatment mean AMH for the exposed group fell to 0.18 ng/mL from baseline mean 1.8 ng/mL (p<0.01), with a median of 1.0 ng/mL.

Includes an economic evaluation

no

Evidence ratings

Level of evidence

II

Risk of bias
Moderate risk of bias Comments:
Result of appraisal

Jutta's tick icon.png Included




Completed by

Dr Jessica Harris

Jutta's tick icon.png This appraisal has been completed.


Article
Cameron KE, Kole MB, Sammel MD, Ginsberg JP, Gosiengfiao Y, Mersereau JE, et al. Acute Menopausal Symptoms in Young Cancer Survivors Immediately following Chemotherapy. Oncology 2018;94(4):200-206 Available from: http://www.ncbi.nlm.nih.gov/pubmed/29393227.
Assigned to
User:Roger.hart
Topic area
Guidelines:COSA:Cancer fertility preservation guidelines/Impact of cancer on fertility
Clinical question
Form
Form:Critical appraisal


Section below only relevant for Cancer Council Project Officer

Edit appraisal assignment