Critical appraisal:Cameron KE, Kole MB, Sammel MD, Ginsberg JP, Gosiengfiao Y, Mersereau JE, et al 2018

Critical Appraisal

Article being appraised

Cameron KE, Kole MB, Sammel MD, Ginsberg JP, Gosiengfiao Y, Mersereau JE, et al. Acute Menopausal Symptoms in Young Cancer Survivors Immediately following Chemotherapy. Oncology 2018;94(4):200-206 Available from: http://www.ncbi.nlm.nih.gov/pubmed/29393227.

Applicable clinical question

Is the ovarian function of female cancer survivors who had cancer treatment, more adversely affected than females in the general population, as measured by markers of their ovarian reserve after treatment?

Key Facts

Study Design

cohort study

Study aims:

to determine the effect on AMH and menopausal symptoms after chemotherapy.

Number of Patients:

124

Reported outcome(s):

decrease in serum AMH 1 month post cessation of chemotherapy

Results of outcome(s):

Levels of AMH decreased after cancer therapy, and lower levels were associated with an increase in prevalence of many symptoms. The post-treatment mean AMH for the exposed group fell to 0.18 ng/mL from baseline mean 1.8 ng/mL (p<0.01), with a median of 1.0 ng/mL.

Includes an economic evaluation

no