Critical appraisal:Canadian Orthopaedic Oncology Society (CANOOS), Moreau LC, Turcotte R, Ferguson P, Wunder J, Clarkson P, et al 2012 2

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Critical Appraisal

Article being appraised

Moreau LC, Turcotte R, Ferguson P, Wunder J, Clarkson P, Masri B, et al. Myxoid\round cell liposarcoma (MRCLS) revisited: an analysis of 418 primarily managed cases. Ann Surg Oncol 2012 Apr;19(4):1081-8 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/22052112.


Applicable clinical question

Key Facts

Study Design

cohort study

Number of Patients:

418


Includes an economic evaluation

no

Evidence ratings

Level of evidence

III-2

Risk of bias
High risk of bias Comments: Though rated low, the study actually looked at a subset of STS (myxoid round cell liposarcoma), and described treatment and outcomes for this group across multiple centres with prospective databases.

Risk of bias assessment: cohort study

Subject selection
"New technology" group
No response
Comparison group
No response
Comparability of groups on demographic characteristics and clinical features
No response
Measurement of outcomes
Outcome measures blind to technology used
No response
Same method of measurement used across comparison groups
No response
Completeness of follow-up
Was follow-up complete and were all patients included in the analysis?
No response
Size of effect
1 Reason for decision: RT reduces LR in patients with positive margins, not significantly in those with -ve margins. On multivariate analysis RT was an independent predictor of local RFS.
Relevance of evidence
1 Additional comments: Majority (74%) received RT, and over half given preop. RT significantly reduced local recurrence on uni/multivariate analyses, effect most pronounced in patients with +ve margins. No effect on survival outcomes.
Result of appraisal

Jutta's tick icon.png Included




Completed by

Dr Marcus Foo FRANZCR


Jutta's tick icon.png This appraisal has been completed.


Article
Moreau LC, Turcotte R, Ferguson P, Wunder J, Clarkson P, Masri B, et al. Myxoid\round cell liposarcoma (MRCLS) revisited: an analysis of 418 primarily managed cases. Ann Surg Oncol 2012 Apr;19(4):1081-8 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/22052112.
Assigned to
User:Marcus.foo
Topic area
Guidelines:Sarcoma
Clinical question
Form
Form:Critical appraisal


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