Critical appraisal:Cancer Prevention Network, Falk GW, Buttar NS, Foster NR, Ziegler KL, Demars CJ, et al 2012

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Critical Appraisal

Article being appraised

Falk GW, Buttar NS, Foster NR, Ziegler KL, Demars CJ, Romero Y, et al. A combination of esomeprazole and aspirin reduces tissue concentrations of prostaglandin E(2) in patients with Barrett's esophagus. Gastroenterology 2012 Oct;143(4):917-26.e1 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/22796132.


Applicable clinical question

Key Facts

Study Design

randomised controlled trial

Number of Patients:

114


Includes an economic evaluation

no

Evidence ratings

Level of evidence

II

Risk of bias
High risk of bias Comments: Please replace this text and include any additional comments in regards to your quality rating

Risk of bias assessment: randomised controlled trial

Was the trial double-blinded?
Outcomes not blinded, substantial side-effects, or not reported.
Was the treatment allocation schedule concealed?
No concealment or unclear (e.g. no approach described, open randomisation lists, person doing recruitment tossing a coin).
Were all randomised participants included in the analysis?
No exclusions or survival analysis used with all subjects included (>95% follow-up for all groups).
The field below is not considered when calculating the risk of bias rating
How was the allocation schedule generated?
Adequate (e.g. random number table, computer random generator, coin tossing, card shuffling)
Size of effect
3 Reason for decision: Please replace this text and briefly describe the reasons for your rating
Relevance of evidence
5 Additional comments: Did not use a cancer relevant outcome
Result of appraisal

Jutta's tick icon.png Included




Completed by

Professor David Watson MBBS, MD, FRACS


Jutta's tick icon.png This appraisal has been completed.


Article
Falk GW, Buttar NS, Foster NR, Ziegler KL, Demars CJ, Romero Y, et al. A combination of esomeprazole and aspirin reduces tissue concentrations of prostaglandin E(2) in patients with Barrett's esophagus. Gastroenterology 2012 Oct;143(4):917-26.e1 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/22796132.
Assigned to
User:David.watson
Topic area
Guidelines:Barrett's
Clinical question
Form
Form:Critical appraisal


Section below only relevant for Cancer Council Project Officer

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