Critical appraisal:Cao Y, Liao C, Tan A, Gao Y, Mo Z, Gao F 2009

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Critical Appraisal

Article being appraised

Cao Y, Liao C, Tan A, Gao Y, Mo Z, Gao F. Meta-analysis of endoscopic submucosal dissection versus endoscopic mucosal resection for tumors of the gastrointestinal tract. Endoscopy 2009 Sep;41(9):751-7 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/19693750.


Applicable clinical question

Key Facts

Study Design

systematic review — Meta-analysis of non-randomised trials

Number of Patients:

2758


Includes an economic evaluation

no

Evidence ratings

Level of evidence

III-2

Risk of bias
Moderate risk of bias Comments: Please replace this text and include any additional comments in regards to your quality rating

Risk of bias assessment: systematic review

Studies included in the review
Was an adequate search strategy used?
Adequate – search terms and/or choice of databases could have been improved upon
Were the inclusion criteria appropriate and applied in an unbiased way?
Yes – pre-specified inclusion criteria applied independently by two people
Were the studies assessed for quality (relating to the minimisation of biases)?
No – quality assessment either not undertaken, inappropriate or not described
Were the characteristics and results of individual studies appropriately summarised?
Yes – summary descriptive tables of subjects, interventions, outcomes etc are provided and estimates of treatment effect displayed
The following questions are only relevant for systematic reviews that pooled data
Were the methods used for pooling the data appropriate?
Yes
If there was heterogeneity, were sources of heterogeneity explored?
Some attempt was made
Size of effect
2 Reason for decision: A clinically important benefit seen for en-bloc and curative resection seen.
Relevance of evidence
2 Additional comments: Explores pooled rates of en-bloc and curative resection with EMR and ESD, but not specifically bleeding, perforation and operative time. Looked at all superficial oesophageal cancers, not specifically adenocarcinoma.
Result of appraisal

Jutta's tick icon.png Included




Completed by

Dr Farzan Fahrtash Bahin, MBBS (Hons), MPhil (Med)


Jutta's tick icon.png This appraisal has been completed.


Article
Cao Y, Liao C, Tan A, Gao Y, Mo Z, Gao F. Meta-analysis of endoscopic submucosal dissection versus endoscopic mucosal resection for tumors of the gastrointestinal tract. Endoscopy 2009 Sep;41(9):751-7 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/19693750.
Assigned to
User:Michael.bourke
Topic area
Guidelines:Barrett's
Clinical question
Form
Form:Critical appraisal


Section below only relevant for Cancer Council Project Officer

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