Critical appraisal:Cardozo ER, Thomson AP, Karmon AE, Dickinson KA, Wright DL, Sabatini ME 2015 3

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Critical Appraisal

Article being appraised

Cardozo ER, Thomson AP, Karmon AE, Dickinson KA, Wright DL, Sabatini ME. Ovarian stimulation and in-vitro fertilization outcomes of cancer patients undergoing fertility preservation compared to age matched controls: a 17-year experience. J Assist Reprod Genet 2015 Apr;32(4):587-96 Available from: http://www.ncbi.nlm.nih.gov/pubmed/25595540.


Applicable clinical question

Key Facts

Study Design

case-control study

Study aims:

dose of gonadotrophin
number oocytes retrieved
number of embryos (2PN)

Number of Patients:

63

63 patients with cancer undergoing 65 cycles with cancer and 122 controls
Reported outcome(s):

no difference in gonadotrophin
no difference no oocytes
no differenc ein embryo number

Results of outcome(s):

no difference in cumulative pregnancy rates
no difference in live birth rates

Comments on results:

Higher rates of ICSI (to avoid failed fertilisation)
high rates of twins in cancer patients ????

Includes an economic evaluation

no

Evidence ratings

Level of evidence

III-2

Risk of bias
Low risk of bias Comments:


Size of effect
4 Reason for decision: small sample size
Relevance of evidence
1 Additional comments: optimum intervention
Result of appraisal

Jutta's tick icon.png Included



Comments

well designed study with clinically important information

Completed by

Rebecca Deans

Jutta's tick icon.png This appraisal has been completed.


Article
Cardozo ER, Thomson AP, Karmon AE, Dickinson KA, Wright DL, Sabatini ME. Ovarian stimulation and in-vitro fertilization outcomes of cancer patients undergoing fertility preservation compared to age matched controls: a 17-year experience. J Assist Reprod Genet 2015 Apr;32(4):587-96 Available from: http://www.ncbi.nlm.nih.gov/pubmed/25595540.
Assigned to
User:Rebecca.deans
Topic area
Guidelines:COSA:Cancer fertility preservation guidelines/Options for treatment
Clinical question
Form
Form:Critical appraisal


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