Critical appraisal:Chao AH, Chang DW, Shuaib SW, Hanasono MM 2012 3

From Clinical Guidelines Wiki

Critical Appraisal

Article being appraised

Chao AH, Chang DW, Shuaib SW, Hanasono MM. The effect of neoadjuvant versus adjuvant irradiation on microvascular free flap reconstruction in sarcoma patients. Plast Reconstr Surg 2012 Mar;129(3):675-82 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/22373973.


Applicable clinical question

Key Facts

Study Design

cohort study

Number of Patients:

119


Includes an economic evaluation

no

Evidence ratings

Level of evidence

III-2

Risk of bias
Moderate risk of bias Comments: Includes heterogenous group with rhabdo, DFSP, Ewing's, chondrosarcomas etc.

Risk of bias assessment: cohort study

Subject selection
"New technology" group
No response
Comparison group
No response
Comparability of groups on demographic characteristics and clinical features
No response
Measurement of outcomes
Outcome measures blind to technology used
No response
Same method of measurement used across comparison groups
No response
Completeness of follow-up
Was follow-up complete and were all patients included in the analysis?
No response
Size of effect
4 Reason for decision: This retrospective study focuses on impact of preop vs postop RT on microvascular free flap reconstruction. In line with other studies, postop RT increases late morbidity. Surprisingly, there was no increase in acute morbidity with preop RT (21%) vs postop RT (37%), p=0.06.
Relevance of evidence
1 Additional comments: Please replace this text and briefly describe the reasons for your rating
Result of appraisal

Jutta's tick icon.png Included




Completed by

Dr Marcus Foo FRANZCR


Jutta's tick icon.png This appraisal has been completed.


Article
Chao AH, Chang DW, Shuaib SW, Hanasono MM. The effect of neoadjuvant versus adjuvant irradiation on microvascular free flap reconstruction in sarcoma patients. Plast Reconstr Surg 2012 Mar;129(3):675-82 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/22373973.
Assigned to
User:Marcus.foo
Topic area
Guidelines:Sarcoma
Clinical question
Form
Form:Critical appraisal


Section below only relevant for Cancer Council Project Officer

Edit appraisal assignment