Critical appraisal:Chemaly M, Scalone O, Durivage G, Napoleon B, Pujol B, Lefort C, et al 2008

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Critical Appraisal

Article being appraised

Chemaly M, Scalone O, Durivage G, Napoleon B, Pujol B, Lefort C, et al. Miniprobe EUS in the pretherapeutic assessment of early esophageal neoplasia. Endoscopy 2008 Jan;40(1):2-6 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/18058614.


Applicable clinical question

Key Facts

Study Design

case series

Number of Patients:

106


Includes an economic evaluation

no

Evidence ratings

Level of evidence

IV

Risk of bias
High risk of bias Comments: This is a single-centre case series of 106 superficial and naive esophageal lesions (52 adenocarcinoma, 54 SCC).

Risk of bias assessment: case series

Subject selection:
Highly selected or not described (e.g. single-institution study)
Were the outcome measures blind to pre/post-intervention?
No, but objective measures used
Follow-up complete and all patients included in the analysis?
Yes (follow-up >95%)
Size of effect
5 Reason for decision: Please replace this text and briefly describe the reasons for your rating
Relevance of evidence
3 Additional comments: This study reported on test accuracy but not on outcomes.
Result of appraisal

Jutta's tick icon.png Included


Reason for decision

Study was not exclusively of patients with adenocarcinoma (i.e. included SCC).

Comments

This retrospective, single-centre case series of 106 superficial oesophageal cancers (52 adenocarcinomas, 54 SCC) found that the overall accuracy, sensitivity, and specificity to differentiate T1sm from T1 m tumors were 73.5 %, 62 %, and 76.5 %, respectively. Overdiagnosis occurred in 18.6 % of the lesions. No statistically significant difference was found in the accuracy of the miniprobe staging between the two lesion types (SCC and adenocarcinoma), and results were significantly poorer in the distal part of the oesophagus. The authors concluded that high-frequency miniprobe examination has a limited accuracy in the detection of submucosal invasion in early oesophageal cancer.

Completed by

Dr Jeremy Dwyer MBBS (Hons)


Jutta's tick icon.png This appraisal has been completed.


Article
Chemaly M, Scalone O, Durivage G, Napoleon B, Pujol B, Lefort C, et al. Miniprobe EUS in the pretherapeutic assessment of early esophageal neoplasia. Endoscopy 2008 Jan;40(1):2-6 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/18058614.
Assigned to
User:Alan.moss
Topic area
Guidelines:Barrett's
Clinical question
Form
Form:Critical appraisal


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