Critical appraisal:Chemoprevention for Barrett's Esophagus Trial Research Group, Heath EI, Canto MI, Piantadosi S, Montgomery E, Weinstein WM, et al 2007

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Critical Appraisal

Article being appraised

Heath EI, Canto MI, Piantadosi S, Montgomery E, Weinstein WM, Herman JG, et al. Secondary chemoprevention of Barrett's esophagus with celecoxib: results of a randomized trial. J Natl Cancer Inst 2007 Apr 4;99(7):545-57 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/17405999.


Applicable clinical question

Key Facts

Study Design

randomised controlled trial

Number of Patients:

222


Includes an economic evaluation

no

Evidence ratings

Level of evidence

II

Risk of bias
Low risk of bias Comments:

Risk of bias assessment: randomised controlled trial

Was the trial double-blinded?
I am reasonably certain that the trial was double-blinded (eg identical placebo, active placebo, double-dummy, no revealing side-effects).
Was the treatment allocation schedule concealed?
Adequately concealed (e.g. central randomisation, numbered or coded bottles, drugs prepared by pharmacy).
Were all randomised participants included in the analysis?
No exclusions or survival analysis used with all subjects included (>95% follow-up for all groups).
The field below is not considered when calculating the risk of bias rating
How was the allocation schedule generated?
Adequate (e.g. random number table, computer random generator, coin tossing, card shuffling)
Size of effect
1 Reason for decision:
Relevance of evidence
1 Additional comments:
Result of appraisal

Jutta's tick icon.png Included




Completed by

Professor David Watson MBBS, MD, FRACS


Jutta's tick icon.png This appraisal has been completed.


Article
Heath EI, Canto MI, Piantadosi S, Montgomery E, Weinstein WM, Herman JG, et al. Secondary chemoprevention of Barrett's esophagus with celecoxib: results of a randomized trial. J Natl Cancer Inst 2007 Apr 4;99(7):545-57 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/17405999.
Assigned to
User:David.watson
Topic area
Guidelines:Barrett's
Clinical question
Form
Form:Critical appraisal


Section below only relevant for Cancer Council Project Officer

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