Critical appraisal:Chen AM, Jahan TM, Jablons DM, Garcia J, Larson DA 2007
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Critical Appraisal
Article being appraised
Chen AM, Jahan TM, Jablons DM, Garcia J, Larson DA. Risk of cerebral metastases and neurological death after pathological complete response to neoadjuvant therapy for locally advanced nonsmall-cell lung cancer: clinical implications for the subsequent management of the brain. Cancer 2007 Apr 15;109(8):1668-75 Available from: http://www.ncbi.nlm.nih.gov/pubmed/17342770.
Applicable clinical question
Key Facts
Study Design
case series
Number of Patients:
51
Includes an economic evaluation
no
Evidence ratings
Level of evidence
IV
Risk of bias
| High risk of bias | Comments: Single institution small retrospective study examining incidence of brain metastases post chemoRT--> surgery |
Size of effect
| 4 | Reason for decision: This is not relevant. This is a retrospective analysis of a cohort of Stage III patients treated with chemoRT f/b surgery and who had pCR to look at incidence of brain relapse. Incidence of brain relapse in this favourable group Stage III patients was 55%. |
Relevance of evidence
| 3 | Additional comments: Relevant for background to brain metastases section. Not about effect of treatment. |
Result of appraisal
Included
Completed by
This appraisal has been completed.
- Article
- Chen AM, Jahan TM, Jablons DM, Garcia J, Larson DA. Risk of cerebral metastases and neurological death after pathological complete response to neoadjuvant therapy for locally advanced nonsmall-cell lung cancer: clinical implications for the subsequent management of the brain. Cancer 2007 Apr 15;109(8):1668-75 Available from: http://www.ncbi.nlm.nih.gov/pubmed/17342770.
- Assigned to
- User:Shalini.vinod
- Topic area
- Guidelines:Lung cancer/Treatment/Non-small-cell stage IV inoperable
- Clinical question
Section below only relevant for Cancer Council Project Officer