Critical appraisal:Chen AM, Jahan TM, Jablons DM, Garcia J, Larson DA 2007

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Critical Appraisal

Article being appraised

Chen AM, Jahan TM, Jablons DM, Garcia J, Larson DA. Risk of cerebral metastases and neurological death after pathological complete response to neoadjuvant therapy for locally advanced nonsmall-cell lung cancer: clinical implications for the subsequent management of the brain. Cancer 2007 Apr 15;109(8):1668-75 Available from: http://www.ncbi.nlm.nih.gov/pubmed/17342770.


Applicable clinical question

Key Facts

Study Design

case series

Number of Patients:

51


Includes an economic evaluation

no

Evidence ratings

Level of evidence

IV

Risk of bias
High risk of bias Comments: Single institution small retrospective study examining incidence of brain metastases post chemoRT--> surgery


Size of effect
4 Reason for decision: This is not relevant. This is a retrospective analysis of a cohort of Stage III patients treated with chemoRT f/b surgery and who had pCR to look at incidence of brain relapse. Incidence of brain relapse in this favourable group Stage III patients was 55%.
Relevance of evidence
3 Additional comments: Relevant for background to brain metastases section. Not about effect of treatment.
Result of appraisal

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Completed by

Associate Professor Shalini Vinod MBBS MD FRANZCR


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Article
Chen AM, Jahan TM, Jablons DM, Garcia J, Larson DA. Risk of cerebral metastases and neurological death after pathological complete response to neoadjuvant therapy for locally advanced nonsmall-cell lung cancer: clinical implications for the subsequent management of the brain. Cancer 2007 Apr 15;109(8):1668-75 Available from: http://www.ncbi.nlm.nih.gov/pubmed/17342770.
Assigned to
User:Shalini.vinod
Topic area
Guidelines:Lung cancer/Treatment/Non-small-cell stage IV inoperable
Clinical question
Form
Form:Critical appraisal


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