Critical appraisal:Chennat J, Konda VJ, Ross AS, de Tejada AH, Noffsinger A, Hart J, et al 2009

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Critical Appraisal

Article being appraised

Chennat J, Konda VJ, Ross AS, de Tejada AH, Noffsinger A, Hart J, et al. Complete Barrett's eradication endoscopic mucosal resection: an effective treatment modality for high-grade dysplasia and intramucosal carcinoma--an American single-center experience. Am J Gastroenterol 2009 Nov;104(11):2684-92 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/19690526.


Applicable clinical question

Key Facts

Study Design

case series

Number of Patients:

49


Includes an economic evaluation

no

Evidence ratings

Level of evidence

IV

Risk of bias
High risk of bias Comments:

Risk of bias assessment: case series

Subject selection:
Highly selected or not described (e.g. single-institution study)
Were the outcome measures blind to pre/post-intervention?
No, but objective measures used
Follow-up complete and all patients included in the analysis?
Yes (follow-up >95%)
Size of effect
1 Reason for decision: Please replace this text and briefly describe the reasons for your rating
Relevance of evidence
1 Additional comments: Retrospective single centre study involving 49 patients with HGD/IMC undergoing EMR and revealing treatment efficacy with bidirectional staging in 45% and a stenosis rate of 37%. This data is directly related to the clinical question at hand and has direct patient relevant clinical outcomes (as opposed to surrogates).
Result of appraisal

Jutta's tick icon.png Included




Completed by

Professor Shan Rajendra MBBCh, MSc, MRCP. MD, FRCP, FRCPE, FRACP


Jutta's tick icon.png This appraisal has been completed.


Article
Chennat J, Konda VJ, Ross AS, de Tejada AH, Noffsinger A, Hart J, et al. Complete Barrett's eradication endoscopic mucosal resection: an effective treatment modality for high-grade dysplasia and intramucosal carcinoma--an American single-center experience. Am J Gastroenterol 2009 Nov;104(11):2684-92 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/19690526.
Assigned to
User:Darren.pavey
Topic area
Guidelines:Barrett's
Clinical question
Form
Form:Critical appraisal


Section below only relevant for Cancer Council Project Officer

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