Critical appraisal:Conio M, Blanchi S, Lapertosa G, Ferraris R, Sablich R, Marchi S, et al 2003

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Critical Appraisal

Article being appraised

Conio M, Blanchi S, Lapertosa G, Ferraris R, Sablich R, Marchi S, et al. Long-term endoscopic surveillance of patients with Barrett's esophagus. Incidence of dysplasia and adenocarcinoma: a prospective study. Am J Gastroenterol 2003 Sep;98(9):1931-9 Available from: http://www.ncbi.nlm.nih.gov/pubmed/14499768.


Applicable clinical question

Key Facts

Study Design

prevalence and incidence study

Number of Patients:

177



Evidence ratings

Risk of bias
High risk of bias Comments: Please replace this text and include any additional comments in regards to your quality rating

Risk of bias assessment: prevalence and incidence study

Source population of patients
Highly selected (single institution) or not described
Subject (sample) selection
Representative of eligible patients (consecutive or random sample e.g. states all patients recruited in given time frame)
Measurement of condition
Objective and reliable (based on registry or other equivalent source)
Follow-up complete and all patients included in the analysis?
Yes (follow-up >95%)
Result of appraisal

Jutta's tick icon.png Included



Comments

HGD was found during surveillance in three patients (1.8%), one with simultaneous AC; two with HGD developed AC later. AC was detected in five male patients
during surveillance. The incidence of AC was 1/220 (5/1100) patient-years of total follow-up, or 1/183.6 (5/918) patient-years in subjects undergoing endoscopy. Four AC patients died.
patients died,

Completed by

Associate Professor Freddy Sitas


Jutta's tick icon.png This appraisal has been completed.


Article
Conio M, Blanchi S, Lapertosa G, Ferraris R, Sablich R, Marchi S, et al. Long-term endoscopic surveillance of patients with Barrett's esophagus. Incidence of dysplasia and adenocarcinoma: a prospective study. Am J Gastroenterol 2003 Sep;98(9):1931-9 Available from: http://www.ncbi.nlm.nih.gov/pubmed/14499768.
Assigned to
User:Freddy.sitas
Topic area
Guidelines:Barrett's
Clinical question
Form
Form:Critical appraisal


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