Critical appraisal:Conio M, Repici A, Cestari R, Blanchi S, Lapertosa G, Missale G, et al 2005 2

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Critical Appraisal

Article being appraised

Conio M, Repici A, Cestari R, Blanchi S, Lapertosa G, Missale G, et al. Endoscopic mucosal resection for high-grade dysplasia and intramucosal carcinoma in Barrett's esophagus: an Italian experience. World J Gastroenterol 2005 Nov 14;11(42):6650-5 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/16425359.


Applicable clinical question

Key Facts

Study Design

case series

Number of Patients:

39


Includes an economic evaluation

no

Evidence ratings

Level of evidence

IV

Risk of bias
Moderate risk of bias Comments: Please replace this text and include any additional comments in regards to your quality rating

Risk of bias assessment: case series

Subject selection:
Selected group (e.g. multi-institution study)
Were the outcome measures blind to pre/post-intervention?
No, but objective measures used
Follow-up complete and all patients included in the analysis?
Yes (follow-up >95%)
Size of effect
5 Reason for decision: Please replace this text and briefly describe the reasons for your rating
Relevance of evidence
2 Additional comments: Please replace this text and briefly describe the reasons for your rating
Result of appraisal

Jutta's tick icon.png Included



Comments

This is a multi-centre, prospective case-series of 39 patients with HGD or IMC in Barrett's oesophagus who underwent EMR. Histopathologic assessment post-resection revealed 5 low-grade dysplasia (LGD) (12.8%), 27 HGD (69.2%), 2 IMC (5.1%), and 5 SMC (-12.8%). EMR changed the pre-treatment diagnosis in 10 patients (25.6%). Three patients with SMC underwent surgery. Histology of the surgical specimen revealed 1 T0N0 and
2 T1N0 lesions. After a median follow-up of 34.9 mo, all patients remained in remission.

Completed by

Dr Jeremy Dwyer MBBS (Hons)


Jutta's tick icon.png This appraisal has been completed.


Article
Conio M, Repici A, Cestari R, Blanchi S, Lapertosa G, Missale G, et al. Endoscopic mucosal resection for high-grade dysplasia and intramucosal carcinoma in Barrett's esophagus: an Italian experience. World J Gastroenterol 2005 Nov 14;11(42):6650-5 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/16425359.
Assigned to
User:Alan.moss
Topic area
Guidelines:Barrett's
Clinical question
Form
Form:Critical appraisal


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