Critical appraisal:Cook MB, Shaheen NJ, Anderson LA, Giffen C, Chow WH, Vaughan TL, et al 2012

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Critical Appraisal

Article being appraised

Cook MB, Shaheen NJ, Anderson LA, Giffen C, Chow WH, Vaughan TL, et al. Cigarette smoking increases risk of Barrett's esophagus: an analysis of the Barrett's and Esophageal Adenocarcinoma Consortium. Gastroenterology 2012 Apr;142(4):744-53 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/22245667.


Applicable clinical question

Key Facts

Study Design

other — Pooled analysis of case-control studies

Number of Patients:

3534


Includes an economic evaluation

no

Evidence ratings

Level of evidence

III-3

Risk of bias
Moderate risk of bias Comments: Pooled analysis of 5 international population-based case-control studies of BE vs controls.
Size of effect
1 Reason for decision: Ever smoking 1.67 (1.04-2.67)


PACK-YEARS

 0       1.0 ref
<15 1.59 (1.02-2.47)
15-<30 1.44 (0.78-2.69)
30-<45 1.99 (1.21-3.29)
>45 1.92 (1.05-3.51)
Relevance of evidence
1 Additional comments: Although the summary evidence rating is low, this is a high-quality observational epidemiological study
Result of appraisal

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Completed by

David Whiteman


Jutta's tick icon.png This appraisal has been completed.


Article
Cook MB, Shaheen NJ, Anderson LA, Giffen C, Chow WH, Vaughan TL, et al. Cigarette smoking increases risk of Barrett's esophagus: an analysis of the Barrett's and Esophageal Adenocarcinoma Consortium. Gastroenterology 2012 Apr;142(4):744-53 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/22245667.
Assigned to
User:David.whiteman
Topic area
Guidelines:Barrett's
Clinical question
Form
Form:Critical appraisal


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