Critical appraisal:Cook MB, Wild CP, Forman D 2005

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Critical Appraisal

Article being appraised

Cook MB, Wild CP, Forman D. A systematic review and meta-analysis of the sex ratio for Barrett's esophagus, erosive reflux disease, and nonerosive reflux disease. Am J Epidemiol 2005 Dec 1;162(11):1050-61 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/16221805.


Applicable clinical question

Key Facts

Study Design

systematic review — Studies could be of any design, but were required to have a sample size of 50+ patients.

Number of Patients:

13074


Includes an economic evaluation

no

Evidence ratings

Level of evidence

IV

Risk of bias
Moderate risk of bias Comments: This was a systematic review of observational studies.

Risk of bias assessment: systematic review

Studies included in the review
Was an adequate search strategy used?
Very thorough – included appropriate search terms and databases
Were the inclusion criteria appropriate and applied in an unbiased way?
No – inclusion was decided in an arbitrary fashion or not described
Were the studies assessed for quality (relating to the minimisation of biases)?
No – quality assessment either not undertaken, inappropriate or not described
Were the characteristics and results of individual studies appropriately summarised?
Yes – summary descriptive tables of subjects, interventions, outcomes etc are provided and estimates of treatment effect displayed
The following questions are only relevant for systematic reviews that pooled data
Were the methods used for pooling the data appropriate?
Yes
If there was heterogeneity, were sources of heterogeneity explored?
Yes
Size of effect
1 Reason for decision: Pooled male/female sex ratio 1.96 (1.77-2.17)
Relevance of evidence
1 Additional comments: This was a systematic review of case-control studies and cross-sectional studies. The NHMRC hierarchy is not clear about the level of evidence for such studies.
Result of appraisal

Jutta's tick icon.png Included




Completed by

Professor David Whiteman B Med Sci, MBBS (Hons) PhD FAFPHM


Jutta's tick icon.png This appraisal has been completed.


Article
Cook MB, Wild CP, Forman D. A systematic review and meta-analysis of the sex ratio for Barrett's esophagus, erosive reflux disease, and nonerosive reflux disease. Am J Epidemiol 2005 Dec 1;162(11):1050-61 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/16221805.
Assigned to
User:David.whiteman
Topic area
Guidelines:Barrett's
Clinical question
Form
Form:Critical appraisal


Section below only relevant for Cancer Council Project Officer

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