Critical appraisal:Cooper BT, Chapman W, Neumann CS, Gearty JC 2006

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Critical Appraisal

Article being appraised

Cooper BT, Chapman W, Neumann CS, Gearty JC. Continuous treatment of Barrett's oesophagus patients with proton pump inhibitors up to 13 years: observations on regression and cancer incidence. Aliment Pharmacol Ther 2006 Mar 15;23(6):727-33 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/16556174.


Applicable clinical question

Key Facts

Study Design

case series

Number of Patients:

188


Includes an economic evaluation

no

Evidence ratings

Level of evidence

IV

Risk of bias
High risk of bias Comments: Retrospective analysis of selected population

Risk of bias assessment: case series

Subject selection:
Highly selected or not described (e.g. single-institution study)
Were the outcome measures blind to pre/post-intervention?
No or not described
Follow-up complete and all patients included in the analysis?
No or not described
Size of effect
5 Reason for decision: Please replace this text and briefly describe the reasons for your rating
Relevance of evidence
5 Additional comments: Evidence of an unproven surrogate outcome (development of squamous islands) in a population of patients with Barrett's treated with PPI.
Result of appraisal

Jutta's tick icon.png Included




Completed by

Dr Adrian Chung MBBS, BMed Sci, FRACP


Jutta's tick icon.png This appraisal has been completed.


Article
Cooper BT, Chapman W, Neumann CS, Gearty JC. Continuous treatment of Barrett's oesophagus patients with proton pump inhibitors up to 13 years: observations on regression and cancer incidence. Aliment Pharmacol Ther 2006 Mar 15;23(6):727-33 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/16556174.
Assigned to
User:Adrian.chung
Topic area
Guidelines:Barrett's
Clinical question
Form
Form:Critical appraisal


Section below only relevant for Cancer Council Project Officer

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