Critical appraisal:Cooper GS, Kou TD, Chak A 2009

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Critical Appraisal

Article being appraised

Cooper GS, Kou TD, Chak A. Receipt of previous diagnoses and endoscopy and outcome from esophageal adenocarcinoma: a population-based study with temporal trends. Am J Gastroenterol 2009 Jun;104(6):1356-62 Available from: http://www.ncbi.nlm.nih.gov/pubmed/19491849.


Applicable clinical question

Key Facts

Study Design

cohort study

Number of Patients:

2754


Includes an economic evaluation

no

Evidence ratings

Level of evidence

III-3

Risk of bias
Low risk of bias Comments: Linked tumour registry health claims database - use of endoscopy as well as diagnosis BE and GERD during 6-36 months prior to diagnosis of adenocarcinoma of the esophagus and the effects of these factors on stage of disease and survival.

Risk of bias assessment: cohort study

Subject selection
"New technology" group
Representative of eligible patients.
Comparison group
Representative of eligible patients
Comparability of groups on demographic characteristics and clinical features
Comparable
Measurement of outcomes
Outcome measures blind to technology used
Yes
Same method of measurement used across comparison groups
Yes
Completeness of follow-up
Was follow-up complete and were all patients included in the analysis?
Yes (follow-up >95%) or survival analysis using all patients
Size of effect
1 Reason for decision: Prior diagnosis of BE associated with significantly earlier stage of diseaes (OR 3.68 95%CI 1.30-10.40)and better survival (HR 0.45, 95%CI 0.25-0.80). Prior diagnosis gerd associated with early stage and prior endoscopy with overall survival.
Relevance of evidence
1 Additional comments: patient relevant outcomes (stage of diease and survival)
Result of appraisal

Jutta's tick icon.png Included




Completed by

Dr Bradley Kendall MBBS, FRACP


Jutta's tick icon.png This appraisal has been completed.


Article
Cooper GS, Kou TD, Chak A. Receipt of previous diagnoses and endoscopy and outcome from esophageal adenocarcinoma: a population-based study with temporal trends. Am J Gastroenterol 2009 Jun;104(6):1356-62 Available from: http://www.ncbi.nlm.nih.gov/pubmed/19491849.
Assigned to
User:Brad.kendall
Topic area
Guidelines:Barrett's
Clinical question
Form
Form:Critical appraisal


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