Critical appraisal:Damani MN, Master V, Meng MV, Burgess C, Turek P, Oates RD 2002

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Critical Appraisal

Article being appraised

Damani MN, Master V, Meng MV, Burgess C, Turek P, Oates RD. Postchemotherapy ejaculatory azoospermia: fatherhood with sperm from testis tissue with intracytoplasmic sperm injection. J Clin Oncol 2002 Feb 15;20(4):930-6 Available from: http://www.ncbi.nlm.nih.gov/pubmed/11844813.


Applicable clinical question

Key Facts

Study Design

case series

Study aims:

To define the success of testis sperm extraction (TESE) and intracytoplasmic sperm injection (ICSI) in azoospermic men with a history of chemotherapy

Number of Patients:

6

23 underwent TESE. In 6 patients cryopreserved tissue used for ICSI. In 9 patients fresh tissue used for ICSI.
Reported outcome(s):

Sperm retrieval rates
Fertilisation rates
Ongoing pregnancy / delivery rate

Results of outcome(s):

Sperm retrieval rates: 15/ 23 patients
Fertilisation rates: 65%
Ongoing pregnancy / delivery rate: 30%

Comments on results:

It is not clear from the results what the results are for the cryopreserved group only

Includes an economic evaluation

no

Evidence ratings

Level of evidence

IV

Risk of bias
High risk of bias Comments:


Size of effect
5 Reason for decision:
Relevance of evidence
1 Additional comments:
Result of appraisal

Jutta's tick icon.png Included




Completed by

Dr Jessica Harris

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Article
Damani MN, Master V, Meng MV, Burgess C, Turek P, Oates RD. Postchemotherapy ejaculatory azoospermia: fatherhood with sperm from testis tissue with intracytoplasmic sperm injection. J Clin Oncol 2002 Feb 15;20(4):930-6 Available from: http://www.ncbi.nlm.nih.gov/pubmed/11844813.
Assigned to
User:Rita.upreti
Topic area
Guidelines:COSA:Cancer fertility preservation guidelines/Options for treatment
Clinical question
Form
Form:Critical appraisal


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