Critical appraisal:Dancey J, Shepherd FA, Gralla RJ, Kim YS 2004

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Critical Appraisal

Article being appraised

Dancey J, Shepherd FA, Gralla RJ, Kim YS. Quality of life assessment of second-line docetaxel versus best supportive care in patients with non-small-cell lung cancer previously treated with platinum-based chemotherapy: results of a prospective, randomized phase III trial. Lung Cancer 2004 Feb;43(2):183-94 Available from: http://www.ncbi.nlm.nih.gov/pubmed/14739039.


Applicable clinical question

Key Facts

Study Design

randomised controlled trial

Number of Patients:

204


Includes an economic evaluation

no

Evidence ratings

Level of evidence

II

Risk of bias
Moderate risk of bias Comments: Treatment assignment was randomised to docetaxel or BSC but could not be blinded. The sample size in the 3 arms of the study arm was relatively small.


Size of effect
2 Reason for decision: There is a small but statistically significant benefit for docetaxel and less deterioration in QoL compared to BSC.
Relevance of evidence
2 Additional comments:
Result of appraisal

Jutta's tick icon.png Included




Completed by

Mustafa Khasraw MBChB MD MRCP FRACP


Jutta's tick icon.png This appraisal has been completed.


Article
Dancey J, Shepherd FA, Gralla RJ, Kim YS. Quality of life assessment of second-line docetaxel versus best supportive care in patients with non-small-cell lung cancer previously treated with platinum-based chemotherapy: results of a prospective, randomized phase III trial. Lung Cancer 2004 Feb;43(2):183-94 Available from: http://www.ncbi.nlm.nih.gov/pubmed/14739039.
Assigned to
User:Nick.pavlakis
Topic area
Guidelines:Lung cancer/Treatment/Non-small-cell stage IV inoperable
Clinical question
Form
Form:Critical appraisal


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