Critical appraisal:DeMeester SR, Campos GM, DeMeester TR, Bremner CG, Hagen JA, Peters JH, et al 1998 2

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Critical Appraisal

Article being appraised

DeMeester SR, Campos GM, DeMeester TR, Bremner CG, Hagen JA, Peters JH, et al. The impact of an antireflux procedure on intestinal metaplasia of the cardia. Ann Surg 1998 Oct;228(4):547-56 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/9790344.


Applicable clinical question

Key Facts

Study Design

case series

Number of Patients:

60


Includes an economic evaluation

no

Evidence ratings

Level of evidence

IV

Risk of bias
High risk of bias Comments: biopsies only looked at by one pathologist

Risk of bias assessment: case series

Subject selection:
Highly selected or not described (e.g. single-institution study)
Were the outcome measures blind to pre/post-intervention?
No, but objective measures used
Follow-up complete and all patients included in the analysis?
Reasonable (follow-up >80%)
Size of effect
5 Reason for decision: no stats; no control group
Relevance of evidence
2 Additional comments: reduction in incidence of surrogate marker (LGD), though other potential reasons for this.
Result of appraisal

Jutta's tick icon.png Included




Completed by

Dr Andrew Taylor MBBS MD FRACP


Jutta's tick icon.png This appraisal has been completed.


Article
DeMeester SR, Campos GM, DeMeester TR, Bremner CG, Hagen JA, Peters JH, et al. The impact of an antireflux procedure on intestinal metaplasia of the cardia. Ann Surg 1998 Oct;228(4):547-56 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/9790344.
Assigned to
User:Andrew.taylor
Topic area
Guidelines:Barrett's
Clinical question
Form
Form:Critical appraisal


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