Critical appraisal:Denschlag D, von Wolff M, Amant F, Kesic V, Reed N, Schneider A, et al 2010 2

Critical Appraisal

Article being appraised

Denschlag D, von Wolff M, Amant F, Kesic V, Reed N, Schneider A, et al. Clinical recommendation on fertility preservation in borderline ovarian neoplasm: ovarian stimulation and oocyte retrieval after conservative surgery. Gynecol Obstet Invest 2010;70(3):160-5 Available from: http://www.ncbi.nlm.nih.gov/pubmed/20558989.

Applicable clinical question

In cancer survivors does the use of assisted reproduction technologies increase the likelihood of cancer recurrence?

Key Facts

Study Design

systematic review — mixed

Number of Patients:

62

Results of outcome(s):

Together with other reports, we calculated a higher
recurrence rate of overall 19.4% which questions the safety
of assisted reproductive techniques in these patients.

Patients with a history of BOT who are seeking treatment for
infertility that, due to the limited data, it is unclear whether
assisted reproductive techniques are associated with an increased
risk of recurrence.

Includes an economic evaluation

no