Critical appraisal:Dolmans MM, Hollanders de Ouderaen S, Demylle D, Pirard C 2015
Critical Appraisal
Dolmans MM, Hollanders de Ouderaen S, Demylle D, Pirard C. Utilization rates and results of long-term embryo cryopreservation before gonadotoxic treatment. J Assist Reprod Genet 2015 Aug;32(8):1233-7 Available from: http://www.ncbi.nlm.nih.gov/pubmed/26174124.
Key Facts
case series
To evaluate long-term embryo cryopreservation, utilization, and success rate in patients subjected to gonadotoxic treatments in the context of cancer.
54
Embryos were obtained from 52 of the 54 patients. Four patients died before their frozen embryos could be thawed.
Of the remaining 48, 9 women returned to use their embryos, resulting in 6 pregnancies (66% cumulative pregnancy rate), two of which ended in miscarriage. The live birth rate per patient was thus 44% (4/9). The true come-back rate, calculated after applicable exclusions, was found to be 23%
no
Evidence ratings
IV
Moderate risk of bias | Comments: It is not stated if all patients undergoing fertility preservation were contacted |
1 | Reason for decision: Although not many women returned for treatment. If they had not undergone storage they could not have conceived. |
1 | Additional comments: |
- Article
- Dolmans MM, Hollanders de Ouderaen S, Demylle D, Pirard C. Utilization rates and results of long-term embryo cryopreservation before gonadotoxic treatment. J Assist Reprod Genet 2015 Aug;32(8):1233-7 Available from: http://www.ncbi.nlm.nih.gov/pubmed/26174124.
- Assigned to
- User:Roger.hart
- Topic area
- Guidelines:COSA:Cancer fertility preservation guidelines/Options for treatment
- Clinical question
Section below only relevant for Cancer Council Project Officer